Striker Issa Alekasir's header in the 88th minute found the back of net and sent the Reds to the competition's next round.
Neuer became goalkeeper of the year, fellow Bayern player Joshua Kimmich was chosen as best defender, while De Bruyne won the prize for the best midfielder. Enditem
But former Changchun Yatai striker Marinho equalized on the stroke of half-time and Kaio Jorge then bundled home from close range to guarantee Santos their fourth win from five matches.
It is the first time ever a side coached by Pep Guardiola has conceded five goals in a competitive match, while Vardy is the first player ever to score two hat-tricks against a side coached by the Catalan.
Alcacer then showed neat footwork halfway through the second half to ensure the points for Villarreal and leave Alaves in trouble.
The 16 teams were divided into two groups this season, with the top four teams in each group moving into Final A for the championship race while the bottom four falling into Final B for the 9th to the 16th places.
Although the club offered no further explanation, merely stating the injury was "pending evolution," it means that Hazard (who didn't play in Madrid's first two matches of the new season) drops out of the squad to face Valladolid in the Alfredo Di Stefano this Wednesday night and makes him a major doubt for the weekend's away trip to play Levante.
DALIAN, China, Sept. 27 (Xinhua) -- Jiangsu Suning defeated Shenzhen FC 1-0 in the 14th round of the Chinese Super League (CSL) here on Sunday, winning a ticket to the second phase.
"I will be competing for the first time since running under two hours at the INEOS 1:59 Challenge. I'm happy to race with the dominant athletes, that is how the sport is and should be treated like that. Competition makes the sport beautiful," he added.
Olimpia must defeat Delfin at home and rely on other results going their way to have any chance of progressing to the knockout phase.
ROME, Sept.27 (Xinhua) -- Andrea Pirlo's Juventus trailed twice at Olimpico Stadium, but leveled each time to draw 2-2 with Roma on Sunday, with Jordan Veretout and Cristiano Ronaldo bagging a brace each.