Milan coach Stefano Pioli benched new signing Sandro Tonali and selected Ibrahimovic to lead the attacking line, flanked by Ante Rebic and Samu Castillejo, with Turk Hakan Calhanoglu behind them.
The only disappointment for Graham Potter's side was a late red card for Yves Bissouma.
Guangzhou still ranks first in the group, and will take on Dalian Pro in the group's last round.
Wuhan ranked fifth with 16 points, only one point behind the fourth-placed Shijiangzhuang Ever Bright and two points behind the third-placed Hebei China fortune, while Chongqing sat sixth with 15 points before the match.
After losing a goal, Wuhan dominated goal possession for a long time but failed to convert. In the second half, Wuhan brought on five substitutes but showed little efficiency in its attacks. In the 86th minute, Marcao extended the lead for Hebei and nailed the game 2-0.
Nakamura Hidemasa, Tokyo 2020 Games delivery officer, speaks during the media briefing on the simplification of the Games in Tokyo, Japan, on Sept. 25, 2020. (Tokyo 2020/Handout via Xinhua)
Betis are another team with two wins from two games after Nabil Fekir's penalty after 10 minutes and William Caravalho's powerful drive from outside the area eight minutes later gave the team from Seville a comfortable 2-0 victory against Valladolid and maintain new coach Manuel Pellegrini's perfect start.
DOHA, Sept. 22 (Xinhua) -- Sharjah scored five goals in the second half for a convincing 6-0 victory over Al Taawoun FC, moving to the second place in Group C of the 2020 AFC Champions League on Monday.
League leaders Saint-Etienne wasted a two-goal lead and missed out on a fourth straight win after drawing 2-2 at Nantes.
In Tuesday's match, Guoan was up by three goals before the interval, with goals from Yu Yang, Jonathan Viera and Fernando Lucas Martins.
Guangzhou regrouped after the interval and levelled in the 71st minute when Wu Chao slotted the ball into the net after collecting a pass from his teammate in the box.